Tripathi, Timir ; Chattopadhyay, Krishnananda (2019) Interaction of α-synuclein with atp synthase: switching role from physiological to pathological ACS Chemical Neuroscience, 10 (1). pp. 16-17. ISSN 1948-7193
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Official URL: http://doi.org/10.1021/acschemneuro.8b00407
Related URL: http://dx.doi.org/10.1021/acschemneuro.8b00407
Abstract
The most abundantly present protein found in Lewy bodies, which is the pathological hallmark of Parkinson’s disease, is α-synuclein. Native monomeric α-synuclein is localized within mitochondria, interacts with ATP synthase subunit, and enhances ATP synthase efficiency and mitochondrial function. Recently, an advanced study shows that the interaction of α-synuclein oligomer with ATP synthase switches its role from physiological to pathological, which leads to mitochondrial dysfunction.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 137136 |
| Deposited On: | 02 Sep 2025 07:26 |
| Last Modified: | 02 Sep 2025 07:26 |
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