Mahapatra, Anindita ; Sarkar, Sukanya ; Biswas, Subhash Chandra ; Chattopadhyay, Krishnananda (2019) An aminoglycoside antibiotic inhibits both lipid-induced and solution-phase fibrillation of α-synuclein in vitro Chemical Communications, 55 (74). pp. 11052-11055. ISSN 1359-7345
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Official URL: http://doi.org/10.1039/C9CC04251B
Related URL: http://dx.doi.org/10.1039/C9CC04251B
Abstract
Parkinson's disease (PD), closely associated with the misfolding and aggregation of the neuronal protein α-synuclein (A-Syn), is a neurodegenerative disorder with no cure to date. Here, we show that the commercially available, inexpensive, aminoglycoside antibiotic kanamycin effectively inhibits both lipid-induced and solution-phase aggregation of A-Syn in vitro, pointing towards the prospective repurposing of kanamycin as a potential anti-PD drug.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 137128 |
| Deposited On: | 02 Sep 2025 07:21 |
| Last Modified: | 02 Sep 2025 07:21 |
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