Bhowmick, Debasish ; Srivastava, Shubhi ; D'Silva, Patrick ; Mugesh, Govindasamy (2015) Highly efficient glutathione peroxidase and peroxiredoxin mimetics protect mammalian cells against oxidative damage Angewandte Chemie, 127 (29). pp. 8569-8573. ISSN 0044-8249
Full text not available from this repository.
Official URL: http://doi.org/10.1002/ange.201502430
Related URL: http://dx.doi.org/10.1002/ange.201502430
Abstract
Novel isoselenazoles with high glutathione peroxidase (GPx) and peroxiredoxin (Prx) activities provide remarkable cytoprotection to human cells, mainly by exhibiting antioxidant activities in the presence of cellular thiols. The cytotoxicity of the isoselenazoles is found to be significantly lower than that of ebselen, which is being clinically evaluated by several groups for the treatment of reperfusion injuries and stroke, hearing loss, and bipolar disorder. The compounds reported in this paper have the potential to be used as therapeutic agents for disorders mediated by reactive oxygen species.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
| ID Code: | 136930 |
| Deposited On: | 10 Sep 2025 12:13 |
| Last Modified: | 10 Sep 2025 12:13 |
Repository Staff Only: item control page
