Singh, Namrata ; Savanur, Mohammed Azharuddin ; Srivastava, Shubhi ; D'Silva, Patrick ; Mugesh, Govindasamy (2017) A redox modulatory Mn3O4 Nanozyme with multi‐enzyme activity provides efficient cytoprotection to human cells in a Parkinson's disease model Angewandte Chemie, 129 (45). pp. 14455-14459. ISSN 00448249
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Official URL: http://doi.org/10.1002/ange.201708573
Related URL: http://dx.doi.org/10.1002/ange.201708573
Abstract
Nanomaterials with enzyme-like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn3O4 nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology-dependent. The redox modulatory effect of Mn3O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multi-enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
| ID Code: | 136916 |
| Deposited On: | 10 Sep 2025 08:06 |
| Last Modified: | 10 Sep 2025 08:06 |
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