Mahalakshmi, Radhakrishnan (2019) Aromatic interactions in β-hairpin scaffold stability: A historical perspective Archives of Biochemistry and Biophysics, 661 . pp. 39-49. ISSN 0003-9861
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Official URL: http://doi.org/10.1016/j.abb.2018.11.001
Related URL: http://dx.doi.org/10.1016/j.abb.2018.11.001
Abstract
Non-covalent interactions between naturally occurring aromatic residues have been widely exploited as scaffold stabilizing agents in de novo designed peptides and in Nature – inspired structures. Our understanding of the factors driving aromatic interactions and their observed interaction geometries have advanced remarkably with improvements in conventional structural studies, availability of novel molecular methods and in silico studies, which have together provided atomistic information on aromatic interactions and interaction strengths. This review attempts to recapitulate the early advances in our understanding of aromatic interactions as stabilizing agents of peptide β-hairpins.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
ID Code: | 136803 |
Deposited On: | 20 Aug 2025 11:19 |
Last Modified: | 20 Aug 2025 11:19 |
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