Aromatic interactions in β-hairpin scaffold stability: A historical perspective

Mahalakshmi, Radhakrishnan (2019) Aromatic interactions in β-hairpin scaffold stability: A historical perspective Archives of Biochemistry and Biophysics, 661 . pp. 39-49. ISSN 0003-9861

Full text not available from this repository.

Official URL: http://doi.org/10.1016/j.abb.2018.11.001

Related URL: http://dx.doi.org/10.1016/j.abb.2018.11.001

Abstract

Non-covalent interactions between naturally occurring aromatic residues have been widely exploited as scaffold stabilizing agents in de novo designed peptides and in Nature – inspired structures. Our understanding of the factors driving aromatic interactions and their observed interaction geometries have advanced remarkably with improvements in conventional structural studies, availability of novel molecular methods and in silico studies, which have together provided atomistic information on aromatic interactions and interaction strengths. This review attempts to recapitulate the early advances in our understanding of aromatic interactions as stabilizing agents of peptide β-hairpins.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:136803
Deposited On:20 Aug 2025 11:19
Last Modified:20 Aug 2025 11:19

Repository Staff Only: item control page