Patil, Kiran M. ; Naik, Rangeetha J. ; Rajpal, . ; Fernandes, Moneesha ; Ganguli, Munia ; Kumar, Vaijayanti A. (2012) Highly Efficient (R-X-R)-Type Carbamates as Molecular Transporters for Cellular Delivery Journal of the American Chemical Society, 134 (17). pp. 7196-7199. ISSN 0002-7863
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Official URL: http://doi.org/10.1021/ja210026m
Related URL: http://dx.doi.org/10.1021/ja210026m
Abstract
The (R-X-R) motif-containing arginine-rich peptides are among the most effective cell-penetrating peptides. The replacement of amide linkages in the (R-X-R) motif by carbamate linkages as in (r-ahx-r)4 or (r-ahx-r-r-apr-r)2 increases the efficacy of such oligomers several-fold. Internalization of these oligomers in mammalian cell lines occurs by an energy-independent process. These oligomers show efficient delivery of biologically active plasmid DNA into CHO-K1 cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 136655 |
| Deposited On: | 24 Jun 2025 12:49 |
| Last Modified: | 24 Jun 2025 12:49 |
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