Iqbal, Babar ; Ali, Javed ; Ganguli, Munia ; Mishra, Sarita ; Baboota, Sanjula (2019) Silymarin-Loaded Nanostructured Lipid Carrier Gel for The Treatment of Skin Cancer Nanomedicine, 14 (9). pp. 1077-1093. ISSN 1743-5889
Full text not available from this repository.
Official URL: http://doi.org/10.2217/nnm-2018-0235
Related URL: http://dx.doi.org/10.2217/nnm-2018-0235
Abstract
Aim: The present study was aimed at determining the antiproliferative, antioxidant, anti-inflammatory and antitumor activity of developed silymarin-nanostructured lipid carrier (NLC) gel. Materials & methods: B16 melanoma cell line and albino mice were used as ex vivo and in vivo models, respectively, to evaluate the aforementioned pharmacological activities. Results: The volume of large tumors significantly (p < 0.05) reduced from 5.02 to 3.05 mm3, levels of IL-1α and TNF-α were significantly (p < 0.001) lower and levels of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) significantly (p < 0.0001) increased in the group treated with silymarin-NLC gel. Furthermore, in skin treated with placebo and conventional gels, a basosquamous carcinoma and squamous cell carcinoma were noticed, respectively. Conclusion: Silymarin-NLC gel presented better treatment outcomes compared with silymarin-conventional gel.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Future Medicine. |
| Keywords: | Antiproliferative Activity; Antitumor Activity; Nanomedicine; Nanostructured Lipid Carrier (NLC); Oxidative Stress; Silymarin; Silymarin-NLC Gel; Skin Cancer; Topical Drug Delivery; Tumor Burden |
| ID Code: | 136602 |
| Deposited On: | 24 Jun 2025 12:29 |
| Last Modified: | 24 Jun 2025 12:29 |
Repository Staff Only: item control page
