Nonimmunogenic Hydrogel-Mediated Delivery of Antibiotics Outperforms Clinically Used Formulations in Mitigating Wound Infections

Kumar, Sandeep ; Pal, Sanjay ; Thakur, Jyoti ; Rani, Parul ; Rana, Kajal ; Kar, Animesh ; Kar, Raunak ; Mehta, Devashish ; Jha, Somesh Kumar ; Pradhan, Manas Kumar ; Jain, Dolly ; Rajput, Kajal ; Mishra, Sarita ; Ganguli, Munia ; Srivastava, Aasheesh ; Dasgupta, Ujjaini ; Patil, Veena S. ; Bajaj, Avinash (2021) Nonimmunogenic Hydrogel-Mediated Delivery of Antibiotics Outperforms Clinically Used Formulations in Mitigating Wound Infections ACS Applied Materials & Interfaces, 13 (37). pp. 44041-44053. ISSN 1944-8244

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Official URL: http://doi.org/10.1021/acsami.1c12265

Related URL: http://dx.doi.org/10.1021/acsami.1c12265

Abstract

Treatment of chronic wound infections caused by Gram-positive bacteria such as Staphylococcus aureus is highly challenging due to the low efficacy of existing formulations, thereby leading to drug resistance. Herein, we present the synthesis of a nonimmunogenic cholic acid-glycine-glycine conjugate (A6) that self-assembles into a supramolecular viscoelastic hydrogel (A6 gel) suitable for topical applications. The A6 hydrogel can entrap different antibiotics with high efficacy without compromising its viscoelastic behavior. Activities against different bacterial species using a disc diffusion assay demonstrated the antimicrobial effect of the ciprofloxacin-loaded A6 hydrogel (CPF-Gel). Immune profiling and gene expression studies after the application of the A6 gel to mice confirmed its nonimmunogenic nature to host tissues. We further demonstrated that topical application of CPF-Gel clears S. aureus-mediated wound infections more effectively than clinically used formulations. Therefore, cholic acid-derived hydrogels are an efficacious matrix for topical delivery of antibiotics and should be explored further.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
Keywords:Antibiotics; Bacterial Infections; Cholic Acid; Hydrogels; Topical Delivery; Wound Infections
ID Code:136592
Deposited On:24 Jun 2025 12:25
Last Modified:24 Jun 2025 12:25

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