Singh, Parminder ; Gollapalli, Kishore ; Mangiola, Stefano ; Schranner, Daniela ; Yusuf, Mohd Aslam ; Chamoli, Manish ; Shi, Sting L. ; Lopes Bastos, Bruno ; Nair, Tripti ; Riermeier, Annett ; Vayndorf, Elena M. ; Wu, Judy Z. ; Nilakhe, Aishwarya ; Nguyen, Christina Q. ; Muir, Michael ; Kiflezghi, Michael G. ; Foulger, Anna ; Junker, Alex ; Devine, Jack ; Sharan, Kunal ; Chinta, Shankar J. ; Rajput, Swati ; Rane, Anand ; Baumert, Philipp ; Schönfelder, Martin ; Iavarone, Francescopaolo ; di Lorenzo, Giorgia ; Kumari, Swati ; Gupta, Alka ; Sarkar, Rajesh ; Khyriem, Costerwell ; Chawla, Amanpreet S. ; Sharma, Ankur ; Sarper, Nazan ; Chattopadhyay, Naibedya ; Biswal, Bichitra K. ; Settembre, Carmine ; Nagarajan, Perumal ; Targoff, Kimara L. ; Picard, Martin ; Gupta, Sarika ; Velagapudi, Vidya ; Papenfuss, Anthony T. ; Kaya, Alaattin ; Ferreira, Miguel Godinho ; Kennedy, Brian K. ; Andersen, Julie K. ; Lithgow, Gordon J. ; Ali, Abdullah Mahmood ; Mukhopadhyay, Arnab ; Palotie, Aarno ; Kastenmüller, Gabi ; Kaeberlein, Matt ; Wackerhage, Henning ; Pal, Bhupinder ; Yadav, Vijay K. (2023) Taurine deficiency as a driver of aging Science, 380 (6649). ISSN 0036-8075
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Official URL: http://doi.org/10.1126/science.abn9257
Related URL: http://dx.doi.org/10.1126/science.abn9257
Abstract
Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Association for the Advancement of Science. |
| ID Code: | 136537 |
| Deposited On: | 24 Jun 2025 09:42 |
| Last Modified: | 24 Jun 2025 09:42 |
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