Subba Reddy, Basireddy V. ; Anusha, Bheemreddy ; Subba Reddy, Ummareddy V. ; Yadav, Jhillu S. ; Suresh Reddy, Cirandur (2013) A Concise and Convergent Total Synthesis of Two Novel Cytotoxic Hydroquinones, Lanneaquinol and (R)-2′-Hydroxylanneaquinol Helvetica Chimica Acta, 96 (10). pp. 1983-1990. ISSN 0018-019X
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Official URL: http://doi.org/10.1002/Hlca.201300066
Related URL: http://dx.doi.org/10.1002/Hlca.201300066
Abstract
A short and efficient approach for the total synthesis of two novel cytotoxic hydroquinones, lanneaquinol (1) and (R)-2′-hydroxylanneaquinol (2) isolated from the organic extract of the plant Lannea welwitschii, has been developed. Enantioselective organocatalytic McMillan hydroxylation has been successfully utilized for the creation of the stereogenic center bearing the OH group of (R)-2′-hydroxylanneaquinol (2). The hydroquinone core was constructed through the alkylation of cyclohexane-1,4-dione with a corresponding aldehyde. Both hydroquinone natural products can be synthesized by a mere change in the synthetic strategy.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
ID Code: | 135751 |
Deposited On: | 14 Aug 2023 04:53 |
Last Modified: | 14 Aug 2023 04:53 |
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