Stereoselective Synthesis of anti-1,3-Aminoalcohols via Reductive Opening of 4-Amidotetrahydropyrans Derived from the Prins/Ritter Sequence

Yadav, J. S. ; Jayasudhan Reddy, Y. ; Adi Narayana Reddy, P. ; Subba Reddy, B. V. (2013) Stereoselective Synthesis of anti-1,3-Aminoalcohols via Reductive Opening of 4-Amidotetrahydropyrans Derived from the Prins/Ritter Sequence Organic Letters, 15 (3). pp. 546-549. ISSN 1523-7060

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Official URL: http://doi.org/10.1021/ol303364j

Related URL: http://dx.doi.org/10.1021/ol303364j

Abstract

A novel method has been devised for anti-1,3-aminoalcohols through reductive elimination of iodomethyltetrahydropyrans which are in turn derived from a Prins/Ritter reaction sequence. The synthetic versatility of this method has been explored in the total synthesis of piperidine alkaloids and β-amino acids.

Item Type:Article
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ID Code:135735
Deposited On:11 Aug 2023 08:55
Last Modified:11 Aug 2023 08:55

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