Cooperative Multicatalytic System for the One-Pot Synthesis of Octahydrospiro-β-carbolines

Subba Reddy, B. V. ; Rajashekhar Reddy, M. ; Yarlagadda, Suresh ; Ravikumar Reddy, C. ; Ravi Kumar, G. ; Yadav, J. S. ; Sridhar, B. (2015) Cooperative Multicatalytic System for the One-Pot Synthesis of Octahydrospiro-β-carbolines Journal of Organic Chemistry, 80 (17). pp. 8807-8814. ISSN 0022-3263

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Official URL: http://doi.org/10.1021/acs.joc.5b01108

Related URL: http://dx.doi.org/10.1021/acs.joc.5b01108

Abstract

A domino cyclization of 3-((3-(2-aminophenyl)prop-2-ynylamino)methyl)but-3-en-1-ol with aldehydes has been accomplished employing 5 mol % of the Ph3PAuCl/AgSbF6/In(OTf)3 system to afford the corresponding octahydrospiro[pyran-4,4'-pyrido[3,4-b]indole] derivatives in good yields with high selectivity. This is the first report on the synthesis of spiro-β-carbolines through a multicatalytic cascade process.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society.
ID Code:135710
Deposited On:10 Aug 2023 10:27
Last Modified:10 Aug 2023 10:27

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