Swapnil, Nipunge ; Kumar, Alleni Suman ; Babu, Nanubolu Jagadeesh ; Yadav, Jhillu Singh (2017) Synthetic Approach Towards the Synthesis of Antimalarial Gomphostenin Asian Journal of Organic Chemistry, 6 (8). pp. 1091-1098. ISSN 2193-5807
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Official URL: http://doi.org/10.1002/Ajoc.201700131
Related URL: http://dx.doi.org/10.1002/Ajoc.201700131
Abstract
An efficient and concise stereoselective synthesis towards the antimalarial (−)-Gomphostenin, starting with the enantiomerically pure Wieland–Miescher ketone, is reported. The key transformations of the convergent synthesis involved a stereoselective reductive allylation, Palladium-catalyzed Saegusa–Ito oxidation, Babler–Dauben oxidative rearrangement, and Wittig olefination reactions. The structure and absolute stereochemistry were determined by X-ray analysis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
| ID Code: | 135695 |
| Deposited On: | 10 Aug 2023 08:19 |
| Last Modified: | 10 Aug 2023 08:19 |
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