Synthesis of Novel 2-Thioxothiazolidin-4-one and Thiazolidine-2, 4-dione Derivatives as Potential Anticancer Agents

Kumar, Alleni Suman ; Kumar, Rathod Aravind ; Reddy, Elala Pravardhan ; Satyanarayana, Vavilapalli ; Kashanna, Jajula ; Reddy, Boggu Jagan Mohan ; Reddy, Basireddy Venkata Subba ; Yadav, Jhillu Singh (2018) Synthesis of Novel 2-Thioxothiazolidin-4-one and Thiazolidine-2, 4-dione Derivatives as Potential Anticancer Agents Natural Product Communications, 13 (5). 1934578X1801300. ISSN 1934-578X

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Official URL: http://doi.org/10.1177/1934578X1801300518

Related URL: http://dx.doi.org/10.1177/1934578X1801300518

Abstract

A variety of novel thiazolidine derivatives (2-thioxothiazolidin-4-one and thiazolidine-2, 4-dione derivatives) have been prepared by using 2,4-diphenyl-2H-chromene-3-carbaldehyde and its derivatives as starting materials. This is the first example of the preparation of thiazolidine derivatives through this novel method. Structure evolution of the resulting thiazolidine derivatives leads to anticancer agents. Our preliminary data for some model compounds on three cancer cell lines (MCF7, A549 and B-16) suggested reasonable anticancer activity against the A549 and B-16 cell lines, with IC50 values of 20.7 and 20.4 μM, respectively. This method is operationally simple and works with a diverse range of substrates.

Item Type:Article
Source:Copyright of this article belongs to SAGE Publications.
ID Code:135674
Deposited On:27 Jul 2023 10:49
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