Fatima, Narjis ; Reddy, B.V. Subba ; Gowravaram, Sabitha ; Yadav, J.S. ; Kadari, Sudhakar ; Putta, Chandra Shekar (2018) Synthesis and biological evaluation of 1-amino isochromans from 2-bromoethyl benzaldehyde and amines in acid medium Bioorganic & Medicinal Chemistry Letters, 28 (2). pp. 196-201. ISSN 0960-894X
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Official URL: http://doi.org/10.1016/j.bmcl.2017.11.020
Related URL: http://dx.doi.org/10.1016/j.bmcl.2017.11.020
Abstract
We have developed a facile and efficient synthetic route to substituted isochromans for the first time by reacting 2-(2-bromoethyl)benzaldehyde with a variety of aryl, heteroaryl amines in AcOH. The reaction is catalyst/additive free and takes place at reflux conditions with short reaction time to furnish products in good to excellent yields. All the compounds have been characterized by spectral techniques such as IR, 1H NMR and Mass etc. Synthesized compounds were evaluated for antimicrobial activity against specific bacterial like 1) Staphylococcus strains aureus 2) Bacillus subtilis 3) Escherichia coli 4) Pseudomonas aeruginosa. Compounds 3e, 3n, 3 m, 3 l, 3 k, 3j and 3b showed most potent in vitro activity against bacterial strains.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier B.V.. |
ID Code: | 135671 |
Deposited On: | 18 Jul 2023 04:39 |
Last Modified: | 18 Jul 2023 04:39 |
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