Correction: Selective Preference of Parallel DNA Triplexes Is Due to the Disruption of Hoogsteen Hydrogen Bonds Caused by the Severe Nonisostericity between the G*GC and T*AT Triplets

Abstract

Frequency of incidence (red & gray filled part) and loss (void part) of canonical (A) Hoogsteen (Sequence 1) and (B) reverse Hoogsteen hydrogen bonds (Sequence 2) in the central 6 G4GC and 7 T4AT triplets of the 15-mer parallel and antiparallel triplex (terminal triplets not considered) over a simulation time of 250 and 100 ns respectively. Wide spread loss of Hoogsteen hydrogen bonds in the (A) parallel triplex (Sequence 1), and retention of reverse Hoogsteen hydrogen bonds in the (B) antiparallel triplex (Sequence 2) are apparent. Canonical Hoogsteen and reverse Hoogsteen hydrogen bonding schemes in the G4GC & T4AT base triplets in parallel &antiparallel orientations are shown on top for reference.