Bano, Nasreen ; Yadav, Manisha ; Das, Bhudev C. (2018) Differential Inhibitory Effects of Curcumin Between HPV+ve and HPV–ve Oral Cancer Stem Cells Frontiers in Oncology, 8 . ISSN 2234-943X
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Official URL: http://doi.org/10.3389/fonc.2018.00412
Related URL: http://dx.doi.org/10.3389/fonc.2018.00412
Abstract
Aim: To investigate the role of a herbal antioxidative compound curcumin on cell proliferation, orosphere formation and miRNA-21 expression in HPV16+ve/–ve oral cancer stem cells. Materials and Methods: Oral cancer stem cells were isolated from HPV+ve/HPV–ve oral cancer cell lines by FACS and stemness markers. MTT, spheroid assay and qRT-PCR were employed to examine the effects of curcumin. Results: Curcumin treatment in micromolar concentration (0–50 μM) demonstrated significant differential inhibition in CSC proliferation, orosphere formation and miRNA-21 expression in a dose dependent manner, the effect being highly pronounced in HPV positive CSCs. Conclusion: The strong and dose-dependent inhibitory effects of curcumin on cell proliferation, stemness and miRNA appear to be due to its chemosensitizing and anticancer effects on OSCC-CSCs.
Item Type: | Article |
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Source: | Copyright of this article belongs to Frontiers Media S.A. |
ID Code: | 135516 |
Deposited On: | 24 Jan 2023 10:20 |
Last Modified: | 24 Jan 2023 10:20 |
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