Pan, Uday Narayan ; Sanpui, Pallab ; Paul, Anumita ; Chattopadhyay, Arun (2019) Protein–Nanoparticle Agglomerates as a Plasmonic Magneto-Luminescent Multifunctional Nanocarrier for Imaging and Combination Therapy ACS Applied Bio Materials, 2 (8). pp. 3144-3152. ISSN 2576-6422
Full text not available from this repository.
Official URL: http://doi.org/10.1021/acsabm.9b00210
Related URL: http://dx.doi.org/10.1021/acsabm.9b00210
Abstract
We report the fabrication of a plasmonic magneto-luminescent multifunctional nanocarrier (PML-MF nanocarrier) by lysozyme-mediated agglomeration of gold-coated iron oxide nanoparticles (IO@AuNPs) and subsequent coating of these agglomerates with BSA-stabilized gold nanoclusters (BSA-AuNCs). The agglomeration-mediated enhancement of plasmonic absorbance at the NIR biological window helped in plasmonic photothermal therapy (PPTT) by PML-MF nanocarriers. PML-MF nanocarriers demonstrated excellent in vitro bioimaging and magnetic targeting capabilities due to the strong photoluminance and superparamagnetism of the constituent AuNCs and IO@AuNPs, respectively. Moreover, these nanocarriers showed the successful loading and delivery of doxorubicin to cancer cells with a significant killing efficiency that could be synergistically improved by combining with PPTT.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 135484 |
| Deposited On: | 24 Jan 2023 08:30 |
| Last Modified: | 24 Jan 2023 08:30 |
Repository Staff Only: item control page
