Pan, Uday Narayan ; Sanpui, Pallab ; Paul, Anumita ; Chattopadhyay, Arun (2018) Synergistic Anticancer Potential of Artemisinin When Loaded with 8-Hydroxyquinoline-Surface Complexed-Zinc Ferrite Magnetofluorescent Nanoparticles and Albumin Composite ACS Applied Bio Materials, 1 (5). pp. 1229-1235. ISSN 2576-6422
Full text not available from this repository.
Official URL: http://doi.org/10.1021/acsabm.8b00358
Related URL: http://dx.doi.org/10.1021/acsabm.8b00358
Abstract
Herein, we report the fabrication of a novel class of magnetofluorescent theranostic nanoparticles (MFTNPs) based on “surface-complexation” of zinc ferrite (ZnFe2O4) NPs with 8-hydroxyquinoline. The potential of these MFTNPs in fluorescence-based bioimaging of different cancer cells was successfully demonstrated. The superparamagnetic behavior of the MFTNPs was exploited effectively in magnetic targeting in vitro. Finally, a well-known hydrophobic antimalarial and prospective anticancer drug artemisinin was efficiently loaded into MFTNPs. Artemisinin loaded MFTNPs were observed to induce superior antiproliferative response, as compared to free drug, in cancer cells in a synergistic mechanism with combination index of 0.1 or less.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| Keywords: | Zinc ferrite nanoparticle; 8-hydroxyquinoline; surface complexation; artemisinin; synergistic antiproliferative efficacy; cancer nanotheranostics |
| ID Code: | 135456 |
| Deposited On: | 24 Jan 2023 05:46 |
| Last Modified: | 24 Jan 2023 05:46 |
Repository Staff Only: item control page
