Dutta, Anushree ; Goswami, Upashi ; Chattopadhyay, Arun (2018) Probing Cancer Cells through Intracellular Aggregation-Induced Emission Kinetic Rate of Copper Nanoclusters ACS Applied Materials & Interfaces, 10 (23). pp. 19459-19472. ISSN 1944-8244
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Official URL: http://doi.org/10.1021/acsami.8b05160
Related URL: http://dx.doi.org/10.1021/acsami.8b05160
Abstract
pH-responsive luminescent copper nanoclusters (Cu NCs) with aggregation-induced emission (AIE) characteristics have been synthesized. Upon internalization into living cells, the NCs displayed a cellular pH environment-dependent luminescence change with orange-red emission at pHi 4.5, whereas bright green emission was observed over time at pHi 7.4, through their AIE attributes. Furthermore, the intracellular AIE kinetics of the NC probe was measured in MCF-7 cells and compared to that of HEK-293 cells. Intriguingly, the intracellular rate constant value derived for AIE kinetics in MCF-7 cells was found to be 3-fold higher than that in HEK-293 cell lines, whereas the value was 2-fold higher than that observed in aqueous medium. This provided a new platform to study different cell lines based on intracellular AIE in living cells, with additional potential for future applications in cellular imaging, diagnostics, and disease detection.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| Keywords: | Copper nanoclusters; photoluminescence; pH; aggregation-induced emission; kinetic rate constant |
| ID Code: | 135447 |
| Deposited On: | 24 Jan 2023 05:35 |
| Last Modified: | 24 Jan 2023 05:35 |
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