Dutta, Deepanjalee ; Sailapu, Sunil Kumar ; Chattopadhyay, Arun ; Ghosh, Siddhartha Sankar (2018) Phenylboronic Acid Templated Gold Nanoclusters for Mucin Detection Using a Smartphone-Based Device and Targeted Cancer Cell Theranostics ACS Applied Materials & Interfaces, 10 (4). pp. 3210-3218. ISSN 1944-8244
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Official URL: http://doi.org/10.1021/acsami.7b13782
Related URL: http://dx.doi.org/10.1021/acsami.7b13782
Abstract
A phenylboronic acid templated gold nanocluster probe was developed to detect biomarker mucin by a noninvasive fluorescence-based method using a point-of-care smartphone-based fluorescence detection device. The gold nanocluster probe is able to detect mucin specifically. The same probe was applied for in vitro targeted bioimaging of HeLa and Hep G2 cancer cells, and it demonstrated specific therapeutic effects toward cancer cells as well as multicellular tumor spheroids imparting theranostic properties. The module is found to be more effective toward HeLa cells, and a pathway of cell death was established using flow-cytometry-based assays.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| Keywords: | Phenylboronic acid; gold nanocluster; fluorescence; point-of-care; smartphone device; mucin; sialic acid; anticancer |
| ID Code: | 135435 |
| Deposited On: | 24 Jan 2023 05:07 |
| Last Modified: | 24 Jan 2023 05:07 |
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