A fluorogenic BODIPY molecular rotor as an apoptosis marker

Ashokkumar, Pichandi ; Ashoka, Anila Hoskere ; Collot, Mayeul ; Das, Amitava ; Klymchenko, Andrey S. (2019) A fluorogenic BODIPY molecular rotor as an apoptosis marker Chemical Communications, 55 (48). pp. 6902-6905. ISSN 1359-7345

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Official URL: http://doi.org/10.1039/C9CC03242H

Related URL: http://dx.doi.org/10.1039/C9CC03242H

Abstract

Based on a BODIPY molecular rotor and a zinc–dipicolylamine receptor, we designed a fluorogenic probe for the detection of apoptosis. Being poorly emissive in solution and with healthy cells, it selectively binds phosphatidylserine of early apoptotic cells and internalizes into late apoptotic cells, lighting up its green fluorescence.

Item Type:Article
Source:Copyright of this article belongs to  Royal Society of Chemistry.
ID Code:135427
Deposited On:24 Jan 2023 04:59
Last Modified:24 Jan 2023 04:59

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