Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters

Basu, Srestha ; Sahoo, Amaresh Kumar ; Paul, Anumita ; Chattopadhyay, Arun (2016) Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters Scientific Reports, 6 (1). ISSN 2045-2322

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Official URL: http://doi.org/10.1038/srep39005

Related URL: http://dx.doi.org/10.1038/srep39005

Abstract

Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presence of Cu2+ ions, recovered in the presence of bilirubin from skin or blood serum. Moreover, the sensitivity of detection of bilirubin was tuneable with the amount of Cu2+ added, thereby facilitating the detection of the desired concentration range of bilirubin.

Item Type:Article
Source:Copyright of this article belongs to Nature Publishing Group
ID Code:135425
Deposited On:24 Jan 2023 04:53
Last Modified:24 Jan 2023 04:53

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