Moitra, Parikshit ; Kumar, Krishan ; Sarkar, Sourav ; Kondaiah, Paturu ; Duan, Wei ; Bhattacharya, Santanu (2017) New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells Chemical Communications, 53 (58). pp. 8184-8187. ISSN 1359-7345
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Official URL: http://doi.org/10.1039/c7cc03320f
Related URL: http://dx.doi.org/10.1039/c7cc03320f
Abstract
A gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 134187 |
| Deposited On: | 05 Jan 2023 10:06 |
| Last Modified: | 05 Jan 2023 10:06 |
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