Hussain, Tabish ; Saha, Dhurjhoti ; Purohit, Gunjan ; Kar, Anirban ; Kishore Mukherjee, Anand ; Sharma, Shalu ; Sengupta, Suman ; Dhapola, Parashar ; Maji, Basudeb ; Vedagopuram, Sreekanth ; Horikoshi, Nobuko T. ; Horikoshi, Nobuo ; Pandita, Raj K. ; Bhattacharya, Santanu ; Bajaj, Avinash ; Riou, Jean-François ; Pandita, Tej K. ; Chowdhury, Shantanu (2017) Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex Scientific Reports, 7 (1). ISSN 2045-2322
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Official URL: http://doi.org/10.1038/s41598-017-11177-1
Related URL: http://dx.doi.org/10.1038/s41598-017-11177-1
Abstract
We observed extra-telomeric binding of the telomere repeat binding factor TRF2 within the promoter of the cyclin-dependent kinase CDKNIA (p21/CIP1/WAF1). This result in TRF2 induced transcription repression of p21. Interestingly, p21 repression was through engagement of the REST-coREST-LSD1-repressor complex and altered histone marks at the p21 promoter in a TRF2-dependent fashion. Furthermore, mutational analysis shows p21 repression requires interaction of TRF2 with a p21 promoter G-quadruplex. Physiologically, TRF2-mediated p21 repression attenuated drug-induced activation of cellular DNA damage response by evading G2/M arrest in cancer cells. Together these reveal for the first time role of TRF2 in REST- repressor complex mediated transcription repression.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Nature Publishing Group. |
| ID Code: | 134183 |
| Deposited On: | 05 Jan 2023 10:03 |
| Last Modified: | 05 Jan 2023 10:03 |
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