Shigdar, Sarah ; Macdonald, Joanna ; O'Connor, Michael ; Wang, Tao ; Xiang, Dongxi ; Al.Shamaileh, Hadi ; Qiao, Liang ; Wei, Ming ; Zhou, Shu-Feng ; Zhu, Yimin ; Kong, Lingxue ; Bhattacharya, Santanu ; Li, ChunGuang ; Duan, Wei (2013) Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation Sensors, 13 (10). pp. 13624-13637. ISSN 1424-8220
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Official URL: http://doi.org/10.3390/s131013624
Related URL: http://dx.doi.org/10.3390/s131013624
Abstract
Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to MDPI. |
| ID Code: | 134116 |
| Deposited On: | 05 Jan 2023 06:34 |
| Last Modified: | 05 Jan 2023 06:34 |
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