Bhattacharya, Santanu ; Varadarajan, Raghavan (2010) Emerging trends at the interface of chemistry and biology: Applications to the design of human therapeutics Journal of Chemical Sciences, 122 (2). pp. 97-107. ISSN 0974-3626
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Official URL: http://doi.org/10.1007/s12039-010-0034-7
Related URL: http://dx.doi.org/10.1007/s12039-010-0034-7
Abstract
This article describes recent developments in the design and implementation of various strategies towards the development of novel therapeutics using first principles from biology and chemistry. Strategies for multi-target therapeutics and network analysis with a focus on cancer and HIV are discussed. Methods for gene and siRNA delivery are presented along with challenges and opportunities for siRNA therapeutics. Advances in protein design methodology and screening are described, with a focus on their application to the design of antibody based therapeutics. Future advances in this area relevant to vaccine design are also mentioned.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Indian Academy of Sciences. |
| ID Code: | 134064 |
| Deposited On: | 03 Jan 2023 11:01 |
| Last Modified: | 03 Jan 2023 11:01 |
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