Batra, Janendra K. ; Chaudhary, Vijay K. ; FitzGerald, David ; Pastan, Ira (1990) TGF α-anti-Tac(Fv)-PE40: a bifunctional toxin cytotoxic for cells with EGF or IL2 receptors Biochemical and Biophysical Research Communications, 171 (1). pp. 1-6. ISSN 0006-291X
Full text not available from this repository.
Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(90)91347-U
Abstract
Conventional immunotoxins and chimeric toxins made in bacteria are directed to only one receptor or antigen on target cells. In this report we describe the construction of a chimeric molecule TGF α -antiTac(Fv)-PE40 which is composed of human transforming growth factor type α attached to anti-Tac(Fv) which is in turn attached to PE40, a form of pseudomonas exotoxin, devoid of its cell recognition domain. TGFα -anti-Tac(Fv)-PE40 is a bifunctional toxin that is produced in E. coli and is active on cells bearing either IL2 or EGF receptors.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 13388 |
| Deposited On: | 11 Nov 2010 08:46 |
| Last Modified: | 17 May 2011 09:43 |
Repository Staff Only: item control page
