A 2-(2′-hydroxyphenyl)benzothiazole (HBT)–quinoline conjugate: a highly specific fluorescent probe for Hg2+ based on ESIPT and its application in bioimaging

Sahana, Sunanda ; Mishra, Gargi ; Sivakumar, Sri ; Bharadwaj, Parimal K. (2015) A 2-(2′-hydroxyphenyl)benzothiazole (HBT)–quinoline conjugate: a highly specific fluorescent probe for Hg2+ based on ESIPT and its application in bioimaging Dalton Transactions, 44 (46). pp. 20139-20146. ISSN 1477-9226

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Official URL: http://doi.org/10.1039/c5dt03719k

Related URL: http://dx.doi.org/10.1039/c5dt03719k

Abstract

A benzothiazole derived chemosensor has been designed based on the excited-state intramolecular proton transfer (ESIPT) mechanism to afford a fluorescence turn-on response specifically in the presence of Hg(2+) ions over a host of biologically relevant metal ions as well as toxic heavy metal ions. The chemosensor exhibits high sensitivity with the detection limit down to 0.11 μM. The metal binding is supported by (1)H NMR titrations, ESI-MS spectral analysis and substantiated by theoretical calculations using the density functional theory. The probe shows cell membrane permeability and efficiency for the detection of Hg(2+) in HeLa cells.

Item Type:Article
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Deposited On:29 Dec 2022 06:57
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