Bidaud, Anne-Laure ; Schwarz, Patrick ; Chowdhary, Anuradha ; Dannaoui, Eric (2022) In Vitro Antifungal Combination of Terbinafine with Itraconazole against Isolates of Trichophyton Species Antimicrobial Agents and Chemotherapy, 66 (1). ISSN 0066-4804
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Official URL: http://doi.org/10.1128/AAC.01449-21
Related URL: http://dx.doi.org/10.1128/AAC.01449-21
Abstract
Terbinafine is used as the first-line therapy for dermatophytosis, but the incidence of terbinafine resistance is increasing. A combination of terbinafine with itraconazole was tested using the checkerboard method based on the EUCAST methodology for antifungal susceptibility testing against 9 terbinafine-susceptible and 7 terbinafine-resistant clinical isolates of Trichophyton spp. from India. Synergistic interactions were observed for 4/9 of the susceptible isolates, with fractional inhibitory concentration index (FICI) values of 0.3125 to 0.5, and for 4/7 of the resistant isolates, with FICI values of 0.032 to 0.3125.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Society for Microbiology. |
| Keywords: | EUCAST; Trichophyton; antifungal combination; dermatophytes; itraconazole; terbinafine. |
| ID Code: | 133398 |
| Deposited On: | 28 Dec 2022 07:34 |
| Last Modified: | 28 Dec 2022 07:34 |
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