Adhya, Samit ; Chatterjee, Mitali ; Hassan, Md Quamarul ; Mukherjee, Sandeep ; Sen, Sandeep (1995) Detection of Leishmania in the blood of early kala-azar patients with the aid of the polymerase chain reaction Transactions of the Royal Society of Tropical Medicine and Hygiene, 89 (6). pp. 622-624. ISSN 00359203
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Official URL: http://doi.org/10.1016/0035-9203(95)90416-6
Related URL: http://dx.doi.org/10.1016/0035-9203(95)90416-6
Abstract
Samples from 39 patients with symptoms suggestive of early visceral leishmaniasis were independently assayed by microscopy of tissue smears, enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) of blood deoxyribonucleic acid. Of these patients, 19 were confirmed as positive or negative by all 3 tests; 11 patients (28%) negative by smear were positive by ELISA and PCR; and 7 (18%) were positive by PCR alone. These results demonstrate the high sensitivity of the non-invasive PCR and, to a smaller extent, ELISA, in the early diagnosis of visceral leishmaniasis.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Oxford University Press |
| Keywords: | visceral leishmaniasis; Leishmania donovani; diagnosis; ELISA; PCR; microscopy; India |
| ID Code: | 133048 |
| Deposited On: | 26 Dec 2022 06:04 |
| Last Modified: | 26 Dec 2022 06:04 |
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