Regio- and enantioselective reduction of diketones: preparation of enantiomerically pure hydroxy ketones catalysed by Candida parapsilosis ATCC 7330

Mahajabeen, Pula ; Chadha, Anju (2015) Regio- and enantioselective reduction of diketones: preparation of enantiomerically pure hydroxy ketones catalysed by Candida parapsilosis ATCC 7330 Tetrahedron: Asymmetry, 26 (20). pp. 1167-1173. ISSN 0957-4166

Full text not available from this repository.

Official URL: http://doi.org/10.1016/j.tetasy.2015.09.001

Related URL: http://dx.doi.org/10.1016/j.tetasy.2015.09.001

Abstract

Enantiomerically enriched hydroxy ketones were prepared by the reduction of the corresponding diketones with excellent enantiomeric excess (98%) and in good yields (up to 75%) using whole cells of Candida parapsilosis ATCC 7330. Cyclic diketones, such as 1,2-cyclohexanedione and 1,4-cyclohexanedione, resulted in hydroxy ketones as products. Cyclohexane-1,3-dione and 5,5-dimethylcyclohexane-1,3-dione gave dimerised products, such as 2,2′-(ethane-1,1-diyl)bis(3-hydroxycyclohex-2-enone) and 2,2′-(ethane-1,1-diyl)bis(3-hydroxy-5,5-dimethylcyclohex-2-enone) with acetaldehyde generated in situ from whole cells of Candida parapsilosis ATCC 7330, which is reported here for the first time.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:132142
Deposited On:14 Dec 2022 06:29
Last Modified:14 Dec 2022 06:29

Repository Staff Only: item control page