Bistability in cell signalling and its significance in identifying potential drug-targets

Abstract

Bistability is one of the salient dynamical features in various all-or-none kinds of decision-making processes. The presence of bistability in a cell signalling network plays a key role in input–output (I/O) relation. Our study is aiming to capture and emphasize the role of motif structure influencing the I/O relation between two nodes in the context of bistability. Here, a model-based analysis is made to investigate the critical conditions responsible for the emergence of different bistable protein–protein interaction (PPI) motifs and their possible applications to find the potential drug-targets.