Voshavar, Chandrashekhar ; Meka, Rakesh C. R. ; Samanta, Sanjoy ; Marepally, Srujan ; Chaudhuri, Arabinda (2017) Enhanced Spacer Length between Mannose Mimicking Shikimoyl and Quinoyl Headgroups and Hydrophobic Region of Cationic Amphiphile Increases Efficiency of Dendritic Cell Based DNA Vaccination: A Structure–Activity Investigation Journal of Medicinal Chemistry, 60 (4). pp. 1605-1610. ISSN 0022-2623
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Official URL: http://doi.org/10.1021/acs.jmedchem.6b01556
Related URL: http://dx.doi.org/10.1021/acs.jmedchem.6b01556
Abstract
In the field of dendritic cell based genetic immunization, previously we showed that liposomes of cationic amphiphiles containing mannose-mimicking shikimoyl headgroup are promising DNA vaccine carriers for dendritic cell (DC) transfection. The present structure–activity study reports on the influence of spacer length (between mannose-mimicking headgroups and quaternary nitrogen centers) in modulating the DC-transfection efficiencies. Further, we report on the anti-melanoma immune response inducing properties of the promising cationic amphiphiles in syngeneic C57BL/6J mice under prophylactic settings.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 132091 |
| Deposited On: | 14 Dec 2022 04:05 |
| Last Modified: | 14 Dec 2022 04:05 |
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