Rajasekar, Shanmugam ; Yadagiri, Dongari ; Anbarasan, Pazhamalai (2015) One-Pot Aminoethylation of Indoles/Pyrroles with Alkynes and Sulfonyl Azides Chemistry - A European Journal, 21 (47). pp. 17079-17084. ISSN 0947-6539
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Official URL: http://doi.org/10.1002/chem.201502201
Related URL: http://dx.doi.org/10.1002/chem.201502201
Abstract
A general and efficient one-pot aminoethylation of substituted indoles/pyrroles was achieved for the synthesis of various tryptamine derivatives employing a combination of alkynes and sulfonyl azides as readily accessible aminoethylating agents. Key features are the successful integration of a copper-catalyzed alkyne and azide cycloaddition to N-sulfonyl-1,2,3-triazole, a rhodium-catalyzed selective insertion of α-iminocarbenes onto the C3H bond of indoles, and a reduction of the resultant enamides to tryptamine derivatives
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
ID Code: | 131838 |
Deposited On: | 09 Dec 2022 04:40 |
Last Modified: | 09 Dec 2022 04:40 |
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