Aminobenzoic acid incorporated octapeptides for cation transport

Benke, Bahiru P. ; Madhavan, Nandita (2015) Aminobenzoic acid incorporated octapeptides for cation transport Bioorganic & Medicinal Chemistry, 23 (7). pp. 1413-1420. ISSN 0968-0896

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Official URL: http://doi.org/10.1016/j.bmc.2015.02.031

Related URL: http://dx.doi.org/10.1016/j.bmc.2015.02.031

Abstract

Robust oligopeptides that mimic natural ion channels are attractive for use as molecular switches or model systems to study ion transport. Herein, we report octapeptides derived from aminobenzoic acid and l/d amino acids. Two of the alanine containing peptides were found to be most active and the peptide containing p-aminobenzoic acid was found to be most active (2.4 times its m-analog). Experimental studies indicate the peptides do not transport halides and transport alkali metal ions.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:131786
Deposited On:08 Dec 2022 08:07
Last Modified:08 Dec 2022 08:07

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