Mamillapalli, N. Chary ; Sekar, Govindasamy (2015) Chemoselective Reductive Deoxygenation and Reduction of α-Keto Amides by using a Palladium Catalyst Advanced Synthesis & Catalysis, 357 (14-15). pp. 3273-3283. ISSN 1615-4150
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Official URL: http://doi.org/10.1002/adsc.201500255
Related URL: http://dx.doi.org/10.1002/adsc.201500255
Abstract
A palladium catalyst is used to synthesize 2,N-diphenylacetamides and α-hydroxy amides from readily available α-keto amides by chemoselective reductive deoxygenation and chemoselective reduction using polymethylhydrosiloxane (PMHS). This methodology has the important advantage in that, just by changing the reaction solvent and temperature, the reaction can be switched from reductive deoxygenation to reduction of α-keto amides. Using this protocol, several biologically important 2,N-diphenylacetamide derivatives and α-hydroxy amides were synthesized.
Item Type: | Article |
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Source: | Copyright of this article belongs to John Wiley and Sons, Inc. |
ID Code: | 131769 |
Deposited On: | 08 Dec 2022 06:41 |
Last Modified: | 08 Dec 2022 06:41 |
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