Mohanty, Maneesha Esther ; Rao, Vaidya Jayathirtha ; Mishra, Ashok Kumar (2014) A fluorescence study on the interaction of telmisartan in triblock polymers pluronic P123 and F127 Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 121 . pp. 330-338. ISSN 1386-1425
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Official URL: http://doi.org/10.1016/j.saa.2013.09.122
Related URL: http://dx.doi.org/10.1016/j.saa.2013.09.122
Abstract
Telmisartan is a poorly soluble drug used in treatment of hypertension. There is a recent interest to use pluronic for improving the solubility and bioavailability of these drugs. In this study the interaction of telmisartan with P123 and F127 has been carried out using steady state and time dependent fluorescence study. Quenching of telmisartan fluorescence by potassium iodide is controlled by interactions arising from collisions and complex formation. A comparison of the fluorescence of telmisartan in pluronics with the well understood fluorescence of 8-anilino-1-naphthalene-sulfonic acid, a known fluorescent molecular probe, indicates that telmisartan is generally present in a relatively polar microenvironment with restricted diffusive motion.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| ID Code: | 131744 |
| Deposited On: | 08 Dec 2022 05:12 |
| Last Modified: | 08 Dec 2022 05:12 |
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