Diversity oriented synthesis of novel haloglycolipids potentially useful for crystallization of integral membrane proteins

Sahoo, Laxminarayan ; Singhamahapatra, Anadi ; Loganathan, Duraikkannu (2014) Diversity oriented synthesis of novel haloglycolipids potentially useful for crystallization of integral membrane proteins Organic and Biomolecular Chemistry, 12 (16). p. 2615. ISSN 1477-0520

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Official URL: http://doi.org/10.1039/c3ob42308e

Related URL: http://dx.doi.org/10.1039/c3ob42308e

Abstract

A series of novel haloglycolipids were synthesized based on Cu(I) catalyzed Huisgen's [3 + 2] cycloaddition reaction of diversely functionalized azides and alkynes, using a mixture of N-bromosuccinimide and Cu(I) halide as the halogen source. Since halogen atoms, like bromine and iodine, with a very high scattering power facilitate the solving of crystal structures, the title haloglycolipids could prove to be invaluable in structure-based drug design involving membrane proteins as targets.

Item Type:Article
Source:Copyright of this article belongs to The Royal Society of Chemistry.
ID Code:131574
Deposited On:07 Dec 2022 07:31
Last Modified:07 Dec 2022 07:31

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