Asymmetric synthesis of anti-convulsive drug (S)-Vigabatrin®

Chandrasekhar, S. ; Mohapatra, Suchismita (1998) Asymmetric synthesis of anti-convulsive drug (S)-Vigabatrin® Tetrahedron Letters, 39 (35). pp. 6415-6418. ISSN 00404039

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Official URL: http://doi.org/10.1016/S0040-4039(98)01324-0

Related URL: http://dx.doi.org/10.1016/S0040-4039(98)01324-0

Abstract

An asymmetric synthesis of fully protected (S) - Vigabatrin® is described using Sharpless asymmetric aminohydroxylation and reductive elimination of α-oxy-β-amino carbonylhydrazone as key steps. Synthesis of (S)-Vigabatrin® is described via Sharpless asymmetric aminohydroxylation and reductive elimination of carbonyl hydrazone.

Item Type:Article
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