Das, Saibal ; Chandrasekhar, Srivari ; Yadav, Jhillu Singh ; Rama Rao, A.V. ; Grée, René (2008) An efficient process for the resolution of cis-4-O-protected-2-cyclopenten-1,4-diol using pancreatin lipase in [C8mim][PF6] as a reusable system Tetrahedron: Asymmetry, 19 (22). pp. 2543-2545. ISSN 09574166
Full text not available from this repository.
Official URL: http://doi.org/10.1016/j.tetasy.2008.11.008
Related URL: http://dx.doi.org/10.1016/j.tetasy.2008.11.008
Abstract
An efficient porcine pancreatin lipase-catalyzed transesterification of cis-4-O-TBS-2-cyclopenten-1,4-diol has been demonstrated in 1-octyl-3-methylimidazolium hexafluorophosphate, [C8mim][PF6] ionic liquid, furnishing both the alcohol and the corresponding acetate in excellent enantiomeric purity and yields. This typical reaction system containing the suspension of enzymes in ionic liquid medium could be reused up to five times to prepare the required products in consistent yields and ee’s. The corresponding optically active derivatives are very useful intermediates towards the synthesis of various types of compounds, including prostanoids.
Item Type: | Article |
---|---|
Source: | Copyright of this article belongs to Elsevier Ltd |
ID Code: | 131429 |
Deposited On: | 06 Dec 2022 13:07 |
Last Modified: | 06 Dec 2022 13:07 |
Repository Staff Only: item control page