Mohanakumara, Patel ; Sreejayan, Nambiar ; Priti, Vaidayanathan ; Ramesha, Bheemanahally Thimmappa ; Ravikanth, Gudasalamani ; Ganeshaiah, Kotiganahalli Narayanagowda ; Vasudeva, Ramesh ; Mohan, John ; Santhoshkumar, Thankayyan Retnabai ; Mishra, Prabhu Dutt ; Ram, Viswakarma ; Uma Shaanker, Ramanan (2010) Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine Fitoterapia, 81 (2). pp. 145-148. ISSN 0367-326X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S03673...
Related URL: http://dx.doi.org/10.1016/j.fitote.2009.08.010
Abstract
Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of several cyclin-dependent kinases (CDKs). Rohitukine was first reported from Amoora rohituka (0.083% dry weight) followed by that in Dysoxylum binectariferum (0.9% dry weight), both belonging to the family Meliaceae. Here, we report incredibly high yields of rohitukine (7% dry weight) in trees of D. binectariferum from the Western Ghats, India. Crude extracts of the tree were found to be highly effective against ovarian and breast cancer lines tested.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Dysoxylum binectariferum; Rohitukine; Anticancer Activity; Flavopiridol |
| ID Code: | 13141 |
| Deposited On: | 11 Nov 2010 06:46 |
| Last Modified: | 14 Feb 2011 09:30 |
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