A chiral pyrrolidine-pyrazole catalyst for the enantioselective Michael addition of carbonyls to nitroolefins

Chandrasekhar, Srivari ; Kumar, Togapur Pavan ; Haribabu, Kothapalli ; Reddy, Chada Raji ; Kumar, Chitumalla Ramesh (2011) A chiral pyrrolidine-pyrazole catalyst for the enantioselective Michael addition of carbonyls to nitroolefins Tetrahedron: Asymmetry, 22 (6). pp. 697-702. ISSN 09574166

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Official URL: http://doi.org/10.1016/j.tetasy.2011.04.010

Related URL: http://dx.doi.org/10.1016/j.tetasy.2011.04.010

Abstract

An enantioselective Michael reaction of carbonyl compounds to nitroolefins has been accomplished using a novel chiral pyrrolidine-pyrazole catalyst. This newly prepared catalyst was found to be very effective in providing good yields as well as good diastereo- and enantio-selectivities. The mechanism of the reaction has also been substantiated by mass spectral studies.

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Deposited On:06 Dec 2022 11:36
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