Kumar, Vemula Praveen ; Chandrasekhar, Srivari (2013) Enantioselective Synthesis of Pladienolide B and Truncated Analogues as New Anticancer Agents Organic Letters, 15 (14). pp. 3610-3613. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/ol401458d
Related URL: http://dx.doi.org/10.1021/ol401458d
Abstract
An enantioselective synthesis of natural anticancer macrolide pladienolide B is described. The synthetic highlights include Sharpless asymmetric epoxidation, ring closing metathesis (RCM), Ireland–Claisen rearrangement, Shi epoxidation, and Pd-catalyzed Stille coupling as key steps. The synthetic route also allowed the synthesis of the truncated analogues (41a–d) of pladienolide B.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 131340 |
| Deposited On: | 06 Dec 2022 10:38 |
| Last Modified: | 06 Dec 2022 10:38 |
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