Sridhar, Chirumarry ; Vijaykumar, Bodduri V. D. ; Radhika, Laghuvarapu ; Shin, Dong-Soo ; Chandrasekhar, Srivari (2014) Asymmetric Formal Synthesis of (+)-Lactacystin European Journal of Organic Chemistry, 2014 (30). pp. 6707-6712. ISSN 1434193X
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Official URL: http://doi.org/10.1002/ejoc.201402700
Related URL: http://dx.doi.org/10.1002/ejoc.201402700
Abstract
A formal synthesis of (+)-lactacystin was achieved from readily available isobutyraldehyde and ethyl acrylate by using a Baylis–Hillman reaction, an intermolecular nucleophilic displacement under Mitsunobu conditions, a Sharpless asymmetric epoxidation, a palladium-catalyzed syn-selective ring opening of an epoxide, an azide reductive lactamization, and a ruthenium-catalyzed oxidation as the key steps.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley & Sons, Inc. |
| ID Code: | 131327 |
| Deposited On: | 06 Dec 2022 10:19 |
| Last Modified: | 06 Dec 2022 10:19 |
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