Anugu, Raghunath Reddy ; Mainkar, Prathama S. ; Sridhar, Balasubramanian ; Chandrasekhar, Srivari (2016) The Ireland–Claisen rearrangement strategy towards the synthesis of the schizophrenia drug, (+)-asenapine Organic & Biomolecular Chemistry, 14 (4). pp. 1332-1337. ISSN 1477-0520
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Official URL: http://doi.org/10.1039/C5OB02047F
Related URL: http://dx.doi.org/10.1039/C5OB02047F
Abstract
(±)-Asenapine, sold in the market as Saphris/Sycrest for the treatment of bipolar disorders, is synthesized in an optically pure form involving an Ireland–Claisen rearrangement as the key step. This approach allows access to all diastereomers.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry |
| ID Code: | 131314 |
| Deposited On: | 06 Dec 2022 10:00 |
| Last Modified: | 06 Dec 2022 10:00 |
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