Formal Total Synthesis of (±)-Cephalotaxine and Congeners via Aryne Insertion Reaction

Gouthami, Pashikanti ; Chegondi, Rambabu ; Chandrasekhar, Srivari (2016) Formal Total Synthesis of (±)-Cephalotaxine and Congeners via Aryne Insertion Reaction Organic Letters, 18 (9). pp. 2044-2046. ISSN 1523-7060

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Official URL: http://doi.org/10.1021/acs.orglett.6b00659

Related URL: http://dx.doi.org/10.1021/acs.orglett.6b00659

Abstract

The formal total synthesis of pentacyclic core alkaloid, (±)-cephalotaxine is achieved in nine steps from known 2-allylpyrrolidine-2-carboxaldehyde using aryne insertion reaction as a key step in 10% overall yield. The developed novel strategy enabled easy access to cephalotaxine congeners

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society
ID Code:131312
Deposited On:06 Dec 2022 09:57
Last Modified:06 Dec 2022 09:57

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