Brønsted Acid Catalyzed Domino Aza-Piancatelli Rearrangement/Michael Reaction: Construction of 1,4-Benzodiazepin-5-ones in One Pot

Nayani, Kiranmai ; Cinsani, Radhika ; Hussaini SD, Anwar ; Mainkar, Prathama S. ; Chandrasekhar, Srivari (2017) Brønsted Acid Catalyzed Domino Aza-Piancatelli Rearrangement/Michael Reaction: Construction of 1,4-Benzodiazepin-5-ones in One Pot European Journal of Organic Chemistry, 2017 (37). pp. 5671-5678. ISSN 1434193X

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Official URL: http://doi.org/10.1002/ejoc.201700957

Related URL: http://dx.doi.org/10.1002/ejoc.201700957

Abstract

A para-toluenesulfonic acid (pTSA) catalyzed domino aza-Piancatelli rearrangement/Michael reaction was developed for the construction of 1,4-benzodiazepin-5-ones in one pot. The method proceeds well in the presence of various furfurylcarbinols and o-aminobenzamides to give products that contain medicinally relevant chemical entities.

Item Type:Article
Source:Copyright of this article belongs to John Wiley & Sons, Inc
ID Code:131299
Deposited On:06 Dec 2022 09:31
Last Modified:06 Dec 2022 09:31

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