Gouthami, Pashikanti ; Chavan, Lahu N. ; Chegondi, Rambabu ; Chandrasekhar, Srivari (2018) Syntheses of 2-Aroyl Benzofurans through Cascade Annulation on Arynes The Journal of Organic Chemistry, 83 (6). pp. 3325-3332. ISSN 0022-3263
Full text not available from this repository.
Official URL: http://doi.org/10.1021/acs.joc.8b00360
Related URL: http://dx.doi.org/10.1021/acs.joc.8b00360
Abstract
The highly efficient and expedient route for the syntheses of 2-aroyl benzofurans has been developed via the cascade [2+2] followed by a [4+1] annulation on arynes. The overall transformation proceeded through the formation of ortho-quinone methide by the insertion of transient aryne into N,N-dimethylformamide and subsequent trapping with sulfur ylide. Moreover, this transformation has a broad range of substrate scope with a high functional-group tolerance. This new reaction was successfully utilized in the synthesis of the potent CYP19 aromatase inhibitor and late-stage functionalization on the bioactive complex estrone.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 131295 |
| Deposited On: | 06 Dec 2022 09:16 |
| Last Modified: | 06 Dec 2022 09:16 |
Repository Staff Only: item control page
