Venkatesh, Telugu ; Mainkar, Prathama S. ; Chandrasekhar, Srivari (2019) Total synthesis of (±)-galanthamine from GABA through regioselective aryne insertion Organic & Biomolecular Chemistry, 17 (8). pp. 2192-2198. ISSN 1477-0520
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Official URL: http://doi.org/10.1039/C8OB03123A
Related URL: http://dx.doi.org/10.1039/C8OB03123A
Abstract
The total synthesis of (±)-galanthamine is achieved in ∼5% overall yield using a key regioselective aryne insertion reaction into a GABA (γ-amino butyric acid) derivative. The strategy presented involves only two sub-critical temperature reactions and less than five chromatographic purifications to achieve the synthesis of galanthamine.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry |
| ID Code: | 131292 |
| Deposited On: | 06 Dec 2022 09:11 |
| Last Modified: | 06 Dec 2022 09:11 |
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